One of the several pains of using crutches is blisters on the base of your hands. There’s a surprising amount of friction at the end opposite your palm. (The other major pain is how much motion planning you have to do. That and not being able to drive.)
It turns out that one of the tricks I learned to inhibit blisters, a medicated anise-smelling tape, leukotape is well suited to solving this problem. A patch over the sore spots makes life more bearable. I suppose you could use other athletic tapes, but this is (for caucasians) more or less skin-coloured and designed for this purpose.
I learned this from section hiker and have told my scouting buddies about it. Mind you, I’m not sure they all listened, but that’s their problem.